正常及嗜酸性粒细胞增多综合征患者嗜酸性粒细胞中的花生四烯酸代谢：白三烯B4、C4、D4及15-脂氧合酶产物的生成
Arachidonic acid metabolism in normal and hypereosinophilic syndrome human eosinophils: generation of leukotrienes B4, C4, D4 and 15-lipoxygenase products.
作者信息
Henderson W R, Harley J B, Fauci A S
出版信息
Immunology. 1984 Apr;51(4):679-86.
Abstract
The formation of 5- and 15-lipoxygenase products of arachidonic acid metabolism was examined in human peripheral blood eosinophils obtained from five normal individuals and five patients with the hypereosinophilic syndrome (HES). Normal and HES eosinophils after stimulation with the calcium ionophore A23187 produced in comparable amounts leukotriene (LT)C4, LTD4, LTB4 and two of its isomers (5-(S),12-(R)-6-trans-LTB4 and 5-(S), 12-(S)-6-trans-LTB4), 15-hydroxy-eicosatetraenoic acid (HETE), 5,15-di-HETE and 8,15-di-HETE. No single lipoxygenase product predominated in the absence of added arachidonic acid whereas 15-HETE was the major product formed when either normal or HES eosinophils were stimulated with A23187 in the presence of added arachidonic acid (10(-4) M).
摘要
在从五名正常个体和五名患有嗜酸性粒细胞增多综合征（HES）的患者获取的人外周血嗜酸性粒细胞中，检测了花生四烯酸代谢产物5-脂氧合酶和15-脂氧合酶产物的形成情况。在用钙离子载体A23187刺激后，正常和HES嗜酸性粒细胞产生的白三烯（LT）C4、LTD4、LTB4及其两种异构体（5-（S），12-（R）-6-反式-LTB4和5-（S），12-（S）-6-反式-LTB4）、15-羟基二十碳四烯酸（HETE）、5,15-二-HETE和8,15-二-HETE的量相当。在未添加花生四烯酸的情况下，没有单一的脂氧合酶产物占主导地位，而当正常或HES嗜酸性粒细胞在添加花生四烯酸（10⁻⁴M）的情况下用A23187刺激时，15-HETE是形成的主要产物。
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