人类单核细胞从T淋巴细胞衍生的花生四烯酸合成类花生酸。
Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid.
作者信息
Goldyne M E, Stobo J D
出版信息
Prostaglandins. 1982 Nov;24(5):623-30. doi: 10.1016/0090-6980(82)90032-6.
PMID:6819603
Abstract
T lymphocytes prelabeled with [14C] arachidonic acid failed to synthesize any eicosanoids even following stimulation with phytohemagglutinin, but they did release free [14C] arachidonic acid. Co-culture of unlabeled monocytes with the prelabeled T lymphocytes resulted in the synthesis of [14C] thromboxane B2, a major monocyte-derived eicosanoid. These data show that monocytes can utilize T lymphocyte-derived arachidonic acid for the synthesis of eicosanoids.
摘要
预先用[14C]花生四烯酸标记的T淋巴细胞，即使在用植物血凝素刺激后也未能合成任何类二十烷酸，但它们确实释放出游离的[14C]花生四烯酸。将未标记的单核细胞与预先标记的T淋巴细胞共培养，导致合成了[14C]血栓素B2，这是一种主要由单核细胞衍生的类二十烷酸。这些数据表明，单核细胞可以利用T淋巴细胞衍生的花生四烯酸来合成类二十烷酸。
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