Eshchar J, Neuman M G, Pavlotzky M, Saibil F G
Int J Tissue React. 1983;5(4):411-4.
A patient with Zollinger-Ellison syndrome who developed an undifferentiated nasopharyngeal carcinoma (NPC) after 3 years of daily treatment with a least 1.0 g cimetidine is described. The question is raised whether large doses of cimetidine, administered for long periods to patients perhaps already immunologically compromised, may change T-suppressor cell functions so as to enable proliferation of oncogenic viruses (e.g. EB virus) and the appearance of tumor. We feel that when the population at risk is small, even a solitary case should alert all concerned.
本文描述了一名患有卓艾综合征的患者，在每天至少服用1.0克西咪替丁治疗3年后发生了未分化鼻咽癌（NPC）。有人提出疑问，对于可能已经存在免疫功能受损的患者长期给予大剂量西咪替丁，是否会改变T抑制细胞功能，从而使致癌病毒（如EB病毒）增殖并导致肿瘤出现。我们认为，当高危人群数量较少时，即使是单个病例也应引起所有相关人员的警惕。
