Mignon M, Vallot T, Galmiche J P, Dupas J L, Bonfils S
Digestion. 1980;20(1):56-61. doi: 10.1159/000198414.
Inhibition of gastric acid secretion by the combined use of cimetidine and pirenzepin has been studied in 5 cases of Zollinger-Ellison syndrome. In 4 acute cases i.v. cimetidine and i.m. pirenzepin were administered together as a treatment and were successful in 3 out of the 4 cases as judged by the disappearance of clinical symptoms and healing of the gastroduodenal and jejunal mucosal ulcerations. Secretory measurements indicated that addition of pirenzepin to cimetidine resulted in larger and more prolonged inhibition of acid secretion in these patients. The continuous record of intragastric pH in the 5th patient, over 24-hour periods, confirmed the above findings. Despite the use of large doses of pirenzepin, no significant side effects were noticed.
在5例卓-艾综合征患者中研究了西咪替丁和哌仑西平联合使用对胃酸分泌的抑制作用。在4例急性病例中，静脉注射西咪替丁和肌肉注射哌仑西平联合作为一种治疗方法，根据临床症状消失以及胃十二指肠和空肠黏膜溃疡愈合情况判断，4例中有3例治疗成功。分泌量测量表明，在这些患者中，哌仑西平与西咪替丁联合使用对胃酸分泌的抑制作用更大且更持久。第5例患者24小时内胃内pH值的连续记录证实了上述发现。尽管使用了大剂量的哌仑西平，但未发现明显的副作用。
