Holoye P, Libnoch J, Cox J, Kun L, Byhardt R, Almagro U, McClelland S, Chintapali K
Int J Radiat Oncol Biol Phys. 1984 Mar;10(3):349-56. doi: 10.1016/0360-3016(84)90053-1.
Among 50 patients with small cell bronchogenic carcinoma who were placed on a protocol of combined chemotherapy and radiation therapy, seven patients developed recurrence in the spinal cord. Five cases terminated in paraplegia and death. One patient with pontine recurrence recovered with local radiation therapy. One patient, diagnosed early, responded to local radiation therapy and is ambulatory. Methods of diagnosis were myelogram, computerized axial tomography, cerebro spinal fluid, chemistry and cytologies. The poor prognosis and the difficulty of diagnosis suggest that we should evaluate prophylactic therapy of the entire cranio-spinal axis.
在50例接受联合化疗和放射治疗方案的小细胞支气管肺癌患者中，有7例出现脊髓复发。5例以截瘫和死亡告终。1例脑桥复发患者经局部放射治疗后康复。1例早期诊断的患者对局部放射治疗有反应，可行走。诊断方法包括脊髓造影、计算机断层扫描、脑脊液检查、化学检查和细胞学检查。预后不良和诊断困难表明我们应该评估整个颅脊髓轴的预防性治疗。
