Kohl S, Harmon M W
J Interferon Res. 1983;3(4):461-3. doi: 10.1089/jir.1983.3.461.
Human neonates are susceptible to severe herpes simplex virus (HSV) infection; however, the immunologic mechanisms explaining this lack of resistance remain to be defined. The ability of leukocytes from adults and neonates to produce interferon (IFN) in response to HSV challenge and to destroy HSV infected cells in the absence of antibody, termed natural killer cytotoxicity (NKC), were compared. The NKC activity of leukocytes from neonates (13.5 +/- 2.5%) was significantly lower (p less than 0.005, Mann Whitney test; p = 0.007, Students t-test) than the NKC activity of adult leukocytes (25.7 +/- 3.2%). In contrast, no significant difference was observed between IFN production by neonate (87.7 +/- 29.1 units) and adult (87.8 +/- 29.4 units) leukocytes.
人类新生儿易患严重的单纯疱疹病毒（HSV）感染；然而，解释这种缺乏抵抗力的免疫机制仍有待确定。比较了成人和新生儿白细胞在受到HSV攻击时产生干扰素（IFN）的能力，以及在没有抗体的情况下破坏HSV感染细胞的能力，即自然杀伤细胞毒性（NKC）。新生儿白细胞的NKC活性（13.5 +/- 2.5%）显著低于成人白细胞的NKC活性（25.7 +/- 3.2%）（曼-惠特尼检验，p小于0.005；学生t检验，p = 0.007）。相比之下，新生儿（87.7 +/- 29.1单位）和成人（87.8 +/- 29.4单位）白细胞产生的IFN之间未观察到显著差异。
