Eggers A E, Tarmin L
J Neurol Sci. 1984 Feb;63(2):147-51. doi: 10.1016/0022-510x(84)90191-6.
A glioblastoma patient was immunized in vitro against autologous tumor cells. Tumor cell immunogens coupled to adjuvant peptide induced direct cell-mediated cytotoxicity, which was measured with a short-term 51chromium release assay. Plain tumor cells were non-antigenic. Cytotoxicity was largely eliminated by erythrocyte-sedimentation of effectors. These results suggest the feasibility of immunizing glioblastoma patients against autologous tumor-associated antigens.
一名胶质母细胞瘤患者在体外接受了针对自体肿瘤细胞的免疫接种。与佐剂肽偶联的肿瘤细胞免疫原诱导了直接的细胞介导细胞毒性，这通过短期的51铬释放试验进行测定。单纯的肿瘤细胞无抗原性。效应细胞的红细胞沉降在很大程度上消除了细胞毒性。这些结果表明对胶质母细胞瘤患者进行针对自体肿瘤相关抗原的免疫接种是可行的。
