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使用共价结合的索状因子类似物来提高肿瘤免疫原性。

Use of covalently bound cord factor analog to increase tumor immunogenicity.

作者信息

Eggers A E, Tarmin L, Ginsburg S

出版信息

J Biol Response Mod. 1984 Aug;3(4):413-22.

PMID:6332882
Abstract

Mice were immunized in vitro and in vivo against the tumor-associated antigens of a methylcholanthrene-induced tumor, using immunogen cells coupled to a cord factor analog (trehalosedihemisuccinatemonohexadecylamide). Immune activity was measured with a short-term 51Cr-release assay. The cord factor analog potentiated immunity induced by adjuvant peptide.

摘要

使用与一种类索状因子（海藻糖二半琥珀酸单十六酰胺）偶联的免疫原细胞，在体外和体内对甲基胆蒽诱导肿瘤的肿瘤相关抗原进行免疫小鼠。通过短期51Cr释放试验测量免疫活性。类索状因子增强了佐剂肽诱导的免疫。

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引用本文的文献

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Autologous adjuvant linked fibroblasts induce anti-glioma immunity: implications for development of a glioma vaccine.自体佐剂连接成纤维细胞诱导抗胶质瘤免疫：对胶质瘤疫苗开发的意义。
J Neurooncol. 2003 Aug-Sep;64(1-2):77-87. doi: 10.1007/BF02700023.
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In vivo immunization against autologous glioblastoma-associated antigens.针对自体胶质母细胞瘤相关抗原的体内免疫。
Cancer Immunol Immunother. 1985;19(1):43-5. doi: 10.1007/BF00199310.