针对自体胶质母细胞瘤相关抗原的体内免疫。
In vivo immunization against autologous glioblastoma-associated antigens.
作者信息
Eggers A E, Tarmin L, Gamboa E T
出版信息
Cancer Immunol Immunother. 1985;19(1):43-5. doi: 10.1007/BF00199310.
Abstract
A glioblastoma patient was immunized in vivo with a mixture of autologous and homologous glioblastoma cells coupled to adjuvant peptide and cord-factor analog. Immune activity of peripheral blood lymphocytes was measured in a short-term 51chromium-release assay against autologous tumor target cells. The patient developed direct cell-mediated cytotoxicity against tumor-associated antigens, which appeared to be T-cell mediated.
摘要
一名胶质母细胞瘤患者接受了体内免疫，免疫所用物质为自体和同源胶质母细胞瘤细胞与佐剂肽及类 cord 因子的混合物。采用短期 51 铬释放试验检测外周血淋巴细胞针对自体肿瘤靶细胞的免疫活性。该患者产生了针对肿瘤相关抗原的直接细胞介导的细胞毒性，这似乎是由 T 细胞介导的。
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