3型脊髓灰质炎病毒特性的研究。II. “热”克隆的特性。
Studies on the characteristics of poliovirus type 3. II. Characteristics of "hot" clones.
作者信息
Jarzabek Z, Sadowski W, Kańtoch M, Magrath D, Krawczyński K
出版信息
Acta Virol. 1976 Oct;20(5):366-72.
PMID:63237
Abstract
Markers d, IST, EA1(OH)3, rct (at sub- and supraoptimal temperatures) and neurovirulence were determined for clones isolated from two lots (S2 and S3) of vaccines containing poliovirus strain Leon 12a1b. Changes of markers rct, d and neurovirulence were observed in several clones isolated from S2 vaccine. No changes were observed in IST and EA1(OH)3 markers.
摘要
对从两批含脊髓灰质炎病毒株Leon 12a1b疫苗（S2和S3）中分离出的克隆株进行了标志物d、IST、EA1(OH)3、rct（在亚最佳和超最佳温度下）和神经毒力的测定。从S2疫苗中分离出的几个克隆株中观察到rct、d和神经毒力标志物的变化。在IST和EA1(OH)3标志物中未观察到变化。
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