仙台病毒特异性T细胞克隆的特征与功能
Characteristics and functions of Sendai virus-specific T-cell clones.
作者信息
Ertl H C, Finberg R W
出版信息
J Virol. 1984 May;50(2):425-31. doi: 10.1128/JVI.50.2.425-431.1984.
Abstract
Several murine Sendai virus-specific T-cell clones were characterized in vitro and in vivo. All T-cell clones were phenotypically Thy-1.2+, and most clones were Lyt-1+,2-; one T-cell clone was Lyt-1-,2-. Some of the clones proliferated in response to antigen presented on I region-compatible stimulator cells. Proliferation could be inhibited by monoclonal antibodies directed against class II antigens. Clones which proliferated in response to antigen secreted lymphokines which could be identified as Interleukin 2 and Interleukin 3. All of the clones tested in vivo induced a delayed-type hypersensitivity response in syngeneic mice challenged with antigens. Depending on the experimental conditions chosen, Interleukin 2-producing clones as well as non-Interleukin 2-producing clones mediated help for stimulation of cytolytic T lymphocytes.
摘要
对几个鼠仙台病毒特异性T细胞克隆进行了体内和体外特性分析。所有T细胞克隆在表型上均为Thy-1.2阳性，大多数克隆为Lyt-1阳性、Lyt-2阴性；一个T细胞克隆为Lyt-1阴性、Lyt-2阴性。一些克隆在与I区相容的刺激细胞上呈递的抗原刺激下发生增殖。增殖可被针对II类抗原的单克隆抗体抑制。对抗原发生增殖反应的克隆分泌的淋巴因子可被鉴定为白细胞介素2和白细胞介素3。所有在体内进行测试的克隆在用抗原攻击的同基因小鼠中均诱导了迟发型超敏反应。根据所选择的实验条件，产生白细胞介素2的克隆以及不产生白细胞介素2的克隆均介导了对细胞毒性T淋巴细胞刺激的辅助作用。
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