仙台病毒特异性T细胞克隆：针对辅助性T细胞克隆的抗独特型抗体诱导细胞毒性T细胞
Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.
作者信息
Ertl H C, Finberg R W
出版信息
Proc Natl Acad Sci U S A. 1984 May;81(9):2850-4. doi: 10.1073/pnas.81.9.2850.
Abstract
We used a monoclonal anti-idiotypic antibody that is directed against a Sendai virus-specific helper T-cell clone to induce an anti-viral immune response in vivo. Splenocytes primed with the anti-idiotypic antibody mediated an antigen-specific cytolytic response. Preimmunization of mice with the anti-idiotypic antibody resulted in protection against a subsequent lethal infection with Sendai virus.
摘要
我们使用了一种针对仙台病毒特异性辅助性T细胞克隆的单克隆抗独特型抗体，以在体内诱导抗病毒免疫反应。用抗独特型抗体致敏的脾细胞介导了抗原特异性溶细胞反应。用抗独特型抗体对小鼠进行预免疫可使其免受随后的仙台病毒致死性感染。
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Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.仙台病毒特异性T细胞克隆：针对辅助性T细胞克隆的抗独特型抗体诱导细胞毒性T细胞
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