Andersen K J, Schjønsby H, Skagen D W, Haga H J
Scand J Gastroenterol. 1983 May;18(3):365-8. doi: 10.3109/00365528309181608.
Highly sensitive techniques have been used for the assay of a range of marker enzymes including lactase, sucrase, alkaline phosphatase, leucyl-beta-naphthylamidase (brush border), and 5'-nucleotidase (basolateral membrane) in jejunal biopsy homogenates from patients with adult coeliac disease with and without steatorrhoea and from a control group. The absorption of D-xylose and vitamin B12 was compared in the two groups with coeliac disease. All enzymes assayed were equally depressed in both groups of coeliac disease as compared with the controls. The absorption of D-xylose and vitamin B12 were reduced in the patients with steatorrhoea compared with those without steatorrhoea. The findings suggest that lack of steatorrhoea in some patients with coeliac disease is due to better preservation of the ileal function rather than to a less severe jejunal mucosal injury.
高灵敏度技术已用于检测一系列标记酶，这些酶包括乳糖酶、蔗糖酶、碱性磷酸酶、亮氨酰-β-萘酰胺酶（刷状缘）和5'-核苷酸酶（基底外侧膜），检测对象为患有成人乳糜泻且有或无脂肪泻的患者以及对照组患者空肠活检匀浆中的这些酶。比较了两组乳糜泻患者对D-木糖和维生素B12的吸收情况。与对照组相比，两组乳糜泻患者中所检测的所有酶均同等程度降低。与无脂肪泻的患者相比，有脂肪泻的患者对D-木糖和维生素B12的吸收减少。这些发现表明，一些乳糜泻患者没有脂肪泻是由于回肠功能保存较好，而非空肠黏膜损伤较轻。
