Mercer J, Eagles M E, Talbot I C
Department of Histopathology, Leicester Royal Infirmary.
J Clin Pathol. 1990 Apr;43(4):307-12. doi: 10.1136/jcp.43.4.307.
Two hundred and ninety four duodenal and jejunal mucosal biopsy specimens from patients with coeliac disease, treated and untreated, and other conditions were examined histologically and by histochemical staining for five peptidase and three disaccharidase enzymes to determine profiles of activity. Suppression of activity paralleled the histology with the following enzymes: lactase, trehalase, brush border endopeptidase, dipeptidyl peptidase II and isomaltase. Lactase, trehalase, and brush border endopeptidase were specifically suppressed in untreated coeliac disease and were diagnostically useful. Examination of a combination of enzymes is recommended.
对294份来自乳糜泻患者（包括接受治疗和未接受治疗的）以及患有其他病症患者的十二指肠和空肠黏膜活检标本进行了组织学检查，并通过组织化学染色检测了五种肽酶和三种双糖酶的活性，以确定其活性谱。以下几种酶的活性抑制情况与组织学表现相符：乳糖酶、海藻糖酶、刷状缘内肽酶、二肽基肽酶II和异麦芽糖酶。乳糖酶、海藻糖酶和刷状缘内肽酶在未经治疗的乳糜泻患者中被特异性抑制，具有诊断价值。建议对多种酶进行联合检测。
