Lucas P, Bogomeletz W V, Cattan A
Sem Hop. 1984 Mar 8;60(11):749-54.
Cutaneous involvement is uncommon in Hodgkin disease. Among 167 Hodgkin patients, we observed skin lesions in four. Clinical and histopathological features are discussed and compared with those of 40 other well-documented cases previously reported in the literature. The wide spectrum of clinical patterns and variability of outcome are underlined. Skin biopsy is mandatory and provides cardinal evidence for diagnosis; however, the Reed Sternberg cell is not absolutely specific and caution must be taken in affirming a disease which implies major therapy. In most observations, skin involvement obviously has no bearing on prognosis. We believe that the reality of specific Hodgkin skin lesions is subject to major reservations.
皮肤受累在霍奇金病中并不常见。在167例霍奇金病患者中，我们观察到4例有皮肤损害。本文讨论了其临床和组织病理学特征，并与文献中先前报道的其他40例有充分记录的病例进行了比较。强调了临床模式的广泛范围和预后的变异性。皮肤活检是必要的，可为诊断提供关键证据；然而，里德·斯腾伯格细胞并非绝对具有特异性，在确诊一种需要进行主要治疗的疾病时必须谨慎。在大多数观察中，皮肤受累显然与预后无关。我们认为，特定的霍奇金皮肤损害的实际情况存在很大疑问。
