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[色甘酸(色甘酸钠)与肥大细胞脱颗粒抑制剂]

[Cromoglycic acid (disodium cromoglycate) and inhibitors of mast cell degranulation].

作者信息

Advenier C, Ruff F

出版信息

Sem Hop. 1984 Feb 23;60(9):659-64.

PMID:6324375
Abstract

Cromoglycic acid (disodium cromoglycate) is a diacromone derived from khelline whose chief action in asthma is preventive, through inhibition of mastocyte degranulation. Since its digestive absorption is poor, it is given locally as a pulverulent aerosol. Cromoglycic acid is also used successfully in certain forms of ocular and nasal allergy. An oral preparation of cromoglycic acid is beginning to be used in food allergy and certain rectocolites. Trials are ongoing with several other substances, which have comparable properties and are active orally.

摘要

色甘酸(色甘酸钠)是一种从凯林提取的二色原酮,其在哮喘中的主要作用是预防性的,通过抑制肥大细胞脱颗粒来实现。由于其消化吸收较差,所以以粉末气雾剂的形式局部给药。色甘酸在某些眼部和鼻部过敏形式中也成功应用。色甘酸的口服制剂开始用于食物过敏和某些直肠结肠炎。目前正在对其他几种具有类似性质且口服有活性的物质进行试验。

相似文献

1
[Cromoglycic acid (disodium cromoglycate) and inhibitors of mast cell degranulation].[色甘酸(色甘酸钠)与肥大细胞脱颗粒抑制剂]
Sem Hop. 1984 Feb 23;60(9):659-64.
2
[Study of disodium cromoglycate action on mast cell degranulation and on heparin release induced by lipid suspension].[色甘酸钠对脂质悬液诱导的肥大细胞脱颗粒及肝素释放作用的研究]
Ann Pharm Fr. 1982 Jul;40(2):105-12.
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[Disodium cromoglycate, DSCG].色甘酸钠,DSCG
Med Monatsschr Pharm. 1985 Feb;8(2):34-6.
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[Disodium cromoglycate and degranulation of rat peritoneal mast cells induced by 48-80].[色甘酸钠与48 - 80诱导的大鼠腹膜肥大细胞脱颗粒]
C R Seances Soc Biol Fil. 1972;166(1):218-20.
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Inhibition of fibrosis in TSK mice by blocking mast cell degranulation.通过阻断肥大细胞脱颗粒抑制TSK小鼠的纤维化。
J Rheumatol. 1987 Apr;14(2):299-301.
6
Current views of the mechanism of action of prophylactic antiallergic drugs.
Allergol Immunopathol (Madr). 1981 Nov-Dec;9(6):501-8.
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Disodium cromoglycate in immunological mast cell degranulation of mice: an experimental study.
Ann Allergy. 1976 Aug;37(2):123-5.
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Cromolyn sodium (disodium cromoglycate) prophylaxis.
Pediatr Clin North Am. 1975 Feb;22(1):141-6. doi: 10.1016/s0031-3955(16)33109-1.
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Sodium cromoglycate: a review.色甘酸钠综述
Eur Respir J Suppl. 1989 Jun;6:556s-560s.
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[Value of disodium cromoglycate (INTAL) in the treatment of obstructive pulmonary diseases (author's transl)].
Z Erkr Atmungsorgane. 1980 Mar;154(3):308-12.

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