Disodium cromoglycate in immunological mast cell degranulation of mice: an experimental study.

Mast cell degranulation occurs at reproducible percentages when the specific antigen is injected into air bubbles of sensitized mice. A fourfold diminution of the degranulated mast cells was observed when 0.25 cc of a 1% solution of DSCG was injected into the bubble prior to the challenging injection. The difference is statistically significant.