Lee V C, Burns R S, Dubois M, Cohen M R
Anesth Analg. 1984 May;63(5):511-4.
Five adult male monkeys (Macaca mulatta) weighing 7.1-9.9 kg were given synthetic human beta-endorphin (800 micrograms) and [14C]methoxy-inulin (50 microCi) in 400 microliters of normal saline intrathecally. Serial samples of cerebrospinal fluid were drawn through a previously positioned indwelling spinal catheter and were assayed for concentrations of beta-endorphin (determined by radioimmunoassay) and inulin (determined by liquid scintillation counter). Spinal fluid concentrations of beta-endorphin and inulin peaked and declined in a parallel manner. The clearance ratio (calculated from the reciprocal of the ratio of the areas under the respective curves of elimination of the two species) remained remarkably similar from animal to animal, giving a mean value of 1.060 +/- 0.090 (SEM). This ratio, being near unity, suggests that beta-endorphin is eliminated from spinal fluid in a fashion similar to that of inulin, which is removed exclusively by bulk absorption.
给5只体重7.1 - 9.9千克的成年雄性猕猴（恒河猴）鞘内注射400微升生理盐水中的合成人β-内啡肽（800微克）和[14C]甲氧基菊粉（50微居里）。通过先前放置的留置脊髓导管抽取脑脊液系列样本，并检测β-内啡肽浓度（通过放射免疫测定法测定）和菊粉浓度（通过液体闪烁计数器测定）。β-内啡肽和菊粉的脑脊液浓度以平行方式达到峰值并下降。清除率（根据两种物质各自消除曲线下面积之比的倒数计算）在不同动物之间保持非常相似，平均值为1.060±0.090（标准误）。该比值接近1，表明β-内啡肽从脑脊液中的消除方式类似于菊粉，菊粉仅通过大量吸收被清除。
