Duarte P A, Chow C C, Simmons F, Ruskin J
Arch Intern Med. 1984 May;144(5):1069-70.
A 67-year-old woman receiving ketoconazole, 200 mg daily for two months, had progressive jaundice, anorexia, and malaise develop. She had greatly elevated liver enzyme levels on hospital admission, and she died as a result of rapidly progressive liver failure. Histologic findings at autopsy disclosed acute hepatic necrosis. There was no clinical or serologic evidence of viral hepatitis. It is suggested that ketoconazole therapy was a causal factor in this case of fatal hepatic failure.
一名67岁女性，每日服用200毫克酮康唑，持续两个月，出现进行性黄疸、厌食和全身不适。入院时肝功能酶水平大幅升高，最终因快速进展的肝衰竭死亡。尸检组织学检查发现急性肝坏死。没有病毒性肝炎的临床或血清学证据。提示酮康唑治疗是该例致命性肝衰竭的病因。
