O'Connor J E, Guerri C, Grisolía S
Biochem Biophys Res Commun. 1984 Mar 15;119(2):516-23. doi: 10.1016/s0006-291x(84)80278-8.
Acute and sustained hyperammonemia in mice resulted in a decrease of the transition temperature of Arrhenium plots of synaptosomal (Na+-K+)ATPase. The activation energies in both phases of the plots were increased. "In vitro" addition of ammonia produced similar changes. This seems to indicate that ammonia alters the physical properties of synaptosomal membranes. The "in vitro" interaction of ammonia and ethanol at the membrane level was also investigated. Both agents together produced a further shift in the transition temperature and affected the activation energies. The relevance of these findings regarding the mechanism of ammonia toxicity and the protective effect of ethanol thereon is discussed.
小鼠急性和持续性高氨血症导致突触体（Na+-K+）ATP酶的阿累尼乌斯曲线转变温度降低。曲线两个阶段的活化能均增加。“体外”添加氨产生了类似变化。这似乎表明氨改变了突触体膜的物理性质。还研究了氨与乙醇在膜水平的“体外”相互作用。两种试剂共同作用使转变温度进一步偏移，并影响了活化能。讨论了这些发现与氨毒性机制及其乙醇对其保护作用的相关性。
