McKinnon P J, Burgoyne L A
Biochem Biophys Res Commun. 1984 Mar 15;119(2):561-6. doi: 10.1016/s0006-291x(84)80285-5.
The level of actin was found to decrease markedly when ataxia telangiectasia lymphoblastoid cells were stepped from low to high density culture conditions. Additionally, as the actin levels decreased the levels of a protein species of 37K daltons increased by orders of magnitude. Partial proteolytic digestion of the 37K protein and actin revealed that the primary structures of these proteins were not related. This phenomena was observed in three out of four ataxia telangiectasia lymphoblastoid cell lines but not in lymphoblastoid cells derived from normal individuals.
当共济失调毛细血管扩张症淋巴母细胞样细胞从低密度培养条件转换为高密度培养条件时，发现肌动蛋白水平显著降低。此外，随着肌动蛋白水平的降低，一种37千道尔顿的蛋白质种类的水平增加了几个数量级。对37K蛋白和肌动蛋白进行部分蛋白酶消化后发现，这些蛋白质的一级结构不相关。在四分之三的共济失调毛细血管扩张症淋巴母细胞样细胞系中观察到了这种现象，但在来自正常个体的淋巴母细胞样细胞中未观察到。
