共济失调毛细血管扩张症：辐射后DNA复制异常。
Ataxia telangiectasia: an anomaly in DNA replication after irradiation.
作者信息
Ford M D, Lavin M F
出版信息
Nucleic Acids Res. 1981 Mar 25;9(6):1395-404. doi: 10.1093/nar/9.6.1395.
Abstract
The effect of increasing dose of gamma-radiation on DNA synthesis in an ataxia telangiectasia lymphoblastoid cell line and a number of control lymphoblastoid cell lines was investigated. No significant inhibition of low molecular weight DNA synthesis was observed in the AT cell line at doses which resulted in considerable inhibition in the control cell lines. At higher doses, 600 to 800 rad, low molecular weight DNA synthesis and chain elongation were enhanced in the AT cell line. At time course study of DNA synthesis after 200 rads of gamma-radiation, revealed no appreciable inhibition of low and high molecular weight DNA synthesis up to 60 minutes postirradiation. However, in control cell lines, overall DNA synthesis was depressed to a level 50% of that shown by the unirradiated cells.
摘要
研究了增加剂量的γ辐射对共济失调毛细血管扩张症淋巴母细胞系以及多个对照淋巴母细胞系中DNA合成的影响。在对照细胞系中导致显著抑制的剂量下，未在共济失调毛细血管扩张症（AT）细胞系中观察到低分子量DNA合成的显著抑制。在更高剂量（600至800拉德）下，AT细胞系中的低分子量DNA合成和链延长增强。对200拉德γ辐射后DNA合成的时间进程研究表明，在照射后60分钟内，低分子量和高分子量DNA合成均未出现明显抑制。然而，在对照细胞系中，总体DNA合成被抑制至未照射细胞所显示水平的50%。
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