Viswanathan S, Sambantham P T, Reddy K, Kameswaran L
Eur J Pharmacol. 1984 Feb 17;98(2):289-91. doi: 10.1016/0014-2999(84)90604-6.
A flavonoid, gossypin, was evaluated for its analgesic action by using acetic acid-induced writhing in mice and was compared with morphine. Gossypin inhibited writhing in a dose-dependent manner. This action was antagonised by naloxone. The pA2 values for morphine-naloxone and gossypin-naloxone were almost identical suggesting a definite involvement of opiate receptors in the analgesic action of gossypin.
通过使用醋酸诱导小鼠扭体实验，对一种类黄酮——棉皮素的镇痛作用进行了评估，并与吗啡进行了比较。棉皮素以剂量依赖性方式抑制扭体反应。这种作用被纳洛酮拮抗。吗啡-纳洛酮和棉皮素-纳洛酮的pA2值几乎相同，表明阿片受体确实参与了棉皮素的镇痛作用。
