环磷酸腺苷（cAMP）对肿瘤启动子介导的细胞间通讯抑制的保护作用。

Protective effect of cAMP on tumor promoter-mediated inhibition of cell-cell communication.

作者信息

Kanno Y, Enomoto T, Shiba Y, Yamasaki H

出版信息

Exp Cell Res. 1984 May;152(1):31-7. doi: 10.1016/0014-4827(84)90227-1.

DOI:10.1016/0014-4827(84)90227-1

Abstract

The formation and maintenance of electrical cell coupling is inhibited by 100 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA). This inhibition could be prevented by db-cAMP and aminophylline when added together with TPA, though they did not restore the cell coupling once it had already been blocked by TPA. It is suggested that db-cAMP affects the early membrane effects of TPA in FL cells.

摘要

100纳克/毫升的12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）可抑制细胞电偶联的形成和维持。当与TPA一起添加时，二丁酰环磷腺苷（db - cAMP）和氨茶碱可防止这种抑制作用，不过一旦细胞偶联已经被TPA阻断，它们并不能恢复细胞偶联。提示db - cAMP影响TPA对FL细胞的早期膜效应。

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