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Protective effect of cAMP on tumor promoter-mediated inhibition of cell-cell communication.

作者信息

Kanno Y, Enomoto T, Shiba Y, Yamasaki H

出版信息

Exp Cell Res. 1984 May;152(1):31-7. doi: 10.1016/0014-4827(84)90227-1.

Abstract

The formation and maintenance of electrical cell coupling is inhibited by 100 ng/ml 12-O-tetradecanoylphorbol-13-acetate (TPA). This inhibition could be prevented by db-cAMP and aminophylline when added together with TPA, though they did not restore the cell coupling once it had already been blocked by TPA. It is suggested that db-cAMP affects the early membrane effects of TPA in FL cells.

摘要

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