Goldyne M E
J Am Acad Dermatol. 1984 Apr;10(4):659-68. doi: 10.1016/s0190-9622(84)80274-1.
The leukotrienes, so named because of their initial identification in leukocyte preparations and the presence of three conjugated double bonds (a conjugated triene), are metabolites of the same polyunsaturated fatty acids (e.g., arachidonic acid) that give rise to the prostaglandins, thromboxanes, and several other families of biologically active lipids. Their potential clinical importance derives from their effects on vascular and other smooth muscle reactivity and on leukocyte function. Several leukotrienes may markedly influence the cellular and vascular responses that constitute an integral part of hypersensitivity and inflammatory reactions of the skin. Preliminary data from several laboratories have been presented that implicate a specific leukotriene in the evolution of the lesions of psoriasis.
白三烯，因其最初在白细胞制剂中被鉴定出来且含有三个共轭双键（共轭三烯）而得名，是与产生前列腺素、血栓素及其他几类生物活性脂质的多不饱和脂肪酸（如花生四烯酸）相同的代谢产物。它们潜在的临床重要性源于其对血管和其他平滑肌反应性以及白细胞功能的影响。几种白三烯可能会显著影响构成皮肤超敏反应和炎症反应组成部分的细胞和血管反应。几个实验室已公布的初步数据表明，一种特定的白三烯与银屑病皮损的演变有关。
