紫苏霉素、地贝卡星与头孢替坦、头孢噻肟、拉氧头孢及头孢磺啶对大肠杆菌、粘质沙雷氏菌和铜绿假单胞菌的联合作用
[Combination action of sisomicin, dibekacin and cefotetan, cefotaxime, latamoxef, and cefsulodin against Escherichia coli, Serratia marcescens, and Pseudomonas aeruginosa].
作者信息
Saito M, Azuma K, Nishino T, Tanino T
出版信息
Jpn J Antibiot. 1983 Oct;36(10):2833-43.
The combined actions of sisomicin (SISO), dibekacin (DKB) and cefotetan (CTT), cefotaxime (CTX), latamoxef (LMOX), cefsulodin (CFS) against E coli KC-14, S. marcescens T-55 and P. aeruginosa E-2 were studied. The following results were obtained. The combination of SISO-CTT, SISO-CTX, SISO-LMOX, SISO-CFS, DKB-CTT, DKB-CTX, DKB-LMOX and DKB-CFS using the checker board dilution method on E. coli KC-14, S. marcescens T-55, P. aeruginosa E-2 were found to have a synergistic effect and the minimum FIC index values were 0.26--0.50 for SISO and 0.28--0.75 for DKB, respectively. With the killing kinetic method, all combinations tested showed a synergistic effect.
研究了西索米星（SISO）、地贝卡星（DKB）与头孢替坦（CTT）、头孢噻肟（CTX）、拉氧头孢（LMOX）、头孢磺啶（CFS）联合对大肠杆菌KC-14、粘质沙雷氏菌T-55和铜绿假单胞菌E-2的作用。得到以下结果。采用棋盘稀释法，在大肠杆菌KC-14、粘质沙雷氏菌T-55、铜绿假单胞菌E-2上，SISO-CTT、SISO-CTX、SISO-LMOX、SISO-CFS、DKB-CTT、DKB-CTX、DKB-LMOX和DKB-CFS联合使用均显示出协同作用，SISO的最低FIC指数值分别为0.26--0.50，DKB的最低FIC指数值分别为0.28--0.75。采用杀菌动力学方法，所有测试的联合用药均显示出协同作用。
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