Kurimoto T, Okachi R
Jpn J Antibiot. 1983 Jul;36(7):1599-603.
In vitro synergistic activities of new aminoglycoside antibiotic micronomicin (MCR, Sagamicin) combined with oxacephem antibiotic latamoxef (LMOX, Siomarin) were investigated. These antibiotics exhibited synergistic activities at FIC index lower than 0.5 against 20.8%, 32.7% and 1.9% of clinical isolates of Pseudomonas aeruginosa (48 strains), Serratia marcescens (52 strains) and Escherichia coli (54 strains), respectively. Partial synergism (0.5 less than FIC index less than 1) was observed in 79.2%, 55.8% and 31.5% of the same microorganisms, too. Each bacteriostatic concentrations of MCR and LMOX showed synergistically bactericidal effects when the drugs were administered at the same time against P. aeruginosa BMH No. 1, S. marcescens F-3283 and E. coli GN2411-5.
研究了新型氨基糖苷类抗生素小诺米星（MCR，相模霉素）与氧头孢烯类抗生素拉氧头孢（LMOX，噻吗灵）的体外协同活性。这些抗生素对铜绿假单胞菌（48株）、粘质沙雷氏菌（52株）和大肠埃希菌（54株）临床分离株的FIC指数低于0.5时，分别表现出20.8%、32.7%和1.9%的协同活性。在相同微生物中，分别有79.2%、55.8%和31.5%观察到部分协同作用（0.5＜FIC指数＜1）。当同时给予MCR和LMOX时，它们各自的抑菌浓度对铜绿假单胞菌BMH No.1、粘质沙雷氏菌F - 3283和大肠埃希菌GN2411 - 5表现出协同杀菌作用。
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