Deguchi K, Yokota N, Koguchi M, Nakane Y, Fukayama S, Nishimura Y, Oda S, Tanaka S, Kato M
Section of Studies Tokyo Clinical Research Center.
Jpn J Antibiot. 1987 Nov;40(11):1895-905.
Antimicrobial activities of sisomicin (SISO) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides (AGs) (gentamicin (GM), tobramycin (TOB), dibekacin (DKB), amikacin (AMK] and 2 cephems (cefotiam, cefotaxime), and were compared to the results reported in the period of late 1970's through early 1980's in Japan. 1. The incidence of SISO-resistant Staphylococcus aureus in the present study was 18% and is comparable to that of the other studies suggesting that the incidence of SISO resistant strains remains on the stable level. The incidence of SISO-resistant Pseudomonas aeruginosa showed the tendency of slight increase. 2. SISO-resistant strains of Enterobacter spp., Serratia marcescens and Citrobacter freundii did not show increase from the 1970/1980 levels. 3. Isolation rates of SISO-resistant indole(+) Proteus varied depending on strains. Isolation rates of SISO-resistant P. vulgaris and Morganella morganii were both as low as 4%, but that of Providencia rettgeri was as high as 60%. Refering to an American study reporting that the Genus Providencia including P. rettgeri showed high incidence of resistance to SISO as well as to GM or TOB, we pointed out that the antimicrobial activity of AGs against Genus Providencia should be evaluated separately from those of other indole(+) Proteus strains. 4. No SISO-resistant strains of Escherichia coli, Klebsiella pneumoniae or P. mirabilis were found. 5. SISO had good antimicrobial activity against most of the investigated species and SISO may still be regarded as one of the clinically useful AGs.
对1986年下半年分离得到的临床菌株，研究了西索米星（SISO）与其他4种氨基糖苷类抗生素（AGs）（庆大霉素（GM）、妥布霉素（TOB）、地贝卡星（DKB）、阿米卡星（AMK））以及2种头孢菌素（头孢替安、头孢噻肟）的抗菌活性，并与日本20世纪70年代末至80年代初报道的结果进行了比较。1. 本研究中耐西索米星金黄色葡萄球菌的发生率为18%，与其他研究结果相当，表明耐西索米星菌株的发生率保持稳定。耐西索米星铜绿假单胞菌的发生率有轻微上升趋势。2. 肠杆菌属、粘质沙雷氏菌和弗氏柠檬酸杆菌的耐西索米星菌株发生率与20世纪70年代/80年代水平相比没有增加。3. 耐西索米星吲哚（+）变形杆菌的分离率因菌株而异。耐西索米星普通变形杆菌和摩根摩根菌的分离率均低至4%，但雷氏普罗威登斯菌的分离率高达60%。参考一项美国研究报告，包括雷氏普罗威登斯菌在内的普罗威登斯菌属对西索米星以及庆大霉素或妥布霉素显示出高耐药率，我们指出，AGs对普罗威登斯菌属的抗菌活性应与其他吲哚（+）变形杆菌菌株分开评估。4. 未发现耐西索米星的大肠杆菌、肺炎克雷伯菌或奇异变形杆菌菌株。5. 西索米星对大多数研究的菌种具有良好的抗菌活性，西索米星仍可被视为临床上有用的AGs之一。
