Fujita S, Yoshida T, Okado N, Matsubara F
Jpn J Antibiot. 1983 Oct;36(10):2887-92.
Antimicrobial susceptibility of 703 nonselected strains of 14 different bacterial species to cefazolin, cefmetazole, cefotiam, cefoperazone latamoxef, and cefotaxime (CTX) was examined. CTX was the most active against E. coli, Klebsiella, Serratia, P. mirabilis, H. influenzae, beta-Streptococcus group A, beta-Streptococcus group B and S. pneumoniae. On the other hand, CTX-resistant (MIC greater than or equal to 50 micrograms/ml) strains were isolated at the following frequencies: Citrobacter, 21.7%; Enterobacter, 7.7%; Serratia, 4.6%; P. aeruginosa, 40.4% and B. fragilis, 28.6%. Of the 411 strains classified as very sensitive () or moderately sensitive (++) by disk method, 405 strains (98.5%) were inhibited by less than or equal to 12.5 micrograms/ml of CTX. Only 1 strain (0.2%) was falsely classified as moderately sensitive and no strains were falsely categorized as resistant.
检测了14种不同细菌的703株未经选择的菌株对头孢唑林、头孢美唑、头孢替安、头孢哌酮、拉氧头孢和头孢噻肟（CTX）的药敏情况。CTX对大肠杆菌、克雷伯菌属、沙雷菌属、奇异变形杆菌、流感嗜血杆菌、A组β溶血性链球菌、B组β溶血性链球菌和肺炎链球菌活性最强。另一方面，CTX耐药（最低抑菌浓度大于或等于50微克/毫升）菌株的分离频率如下：柠檬酸杆菌属，21.7%；肠杆菌属，7.7%；沙雷菌属，4.6%；铜绿假单胞菌，40.4%；脆弱拟杆菌，28.6%。在通过纸片法分类为极敏感（）或中度敏感（++）的411株菌株中，405株（98.5%）被小于或等于12.5微克/毫升的CTX抑制。仅1株（0.2%）被错误分类为中度敏感，无菌株被错误分类为耐药。
