Steffen D
Proc Natl Acad Sci U S A. 1984 Apr;81(7):2097-101. doi: 10.1073/pnas.81.7.2097.
Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.
对61例鼠白血病病毒诱导的淋巴瘤进行检查，以寻找与已知癌基因相邻的前病毒插入证据。发现其中5例淋巴瘤在c-myc基因附近存在改变。对2例c-myc序列发生改变的淋巴瘤进行了详细检查。获得的证据表明，这2例淋巴瘤中c-myc序列的改变是前病毒整合的结果。这一结果提示，鼠白血病病毒诱导的淋巴瘤发生可能是由于细胞癌基因的插入诱变所致。
