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百日咳博德特氏菌中吡啶核苷酸循环的初步证据。

Preliminary evidence for a pyridine nucleotide cycle in Bordetella pertussis.

作者信息

McPheat W L

出版信息

Antonie Van Leeuwenhoek. 1984;50(1):33-7. doi: 10.1007/BF00404905.

DOI:10.1007/BF00404905
PMID:6326669
Abstract

Preliminary evidence that Bordetella pertussis has a functional pyridine nucleotide cycle was the observation that [14C]-nicotinic acid was rapidly metabolized during its uptake by the bacteria to pyridine nucleotides and nicotinamide. Nicotinamide deamidase activity, necessary for the completion of the cycle by conversion of nicotinamide to nicotinic acid, was found in a soluble extract (20 000 X g supernatant) of B. pertussis cell lysates.

摘要

百日咳博德特氏菌具有功能性吡啶核苷酸循环的初步证据是观察到,[14C] - 烟酸在被细菌摄取过程中迅速代谢为吡啶核苷酸和烟酰胺。在百日咳博德特氏菌细胞裂解物的可溶性提取物(20000×g上清液)中发现了烟酰胺脱氨酶活性,该活性是通过将烟酰胺转化为烟酸来完成循环所必需的。

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本文引用的文献

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Inhibition of nicotinic acid and nicotinamide uptake into Bordetella pertussis by structural analogues.
J Gen Microbiol. 1982 Nov;128(11):2681-5. doi: 10.1099/00221287-128-11-2681.
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Pyridine nucleotide cycle of Salmonella typhimurium: in vitro demonstration of nicotinamide adenine dinucleotide glycohydrolase, nicotinamide mononucleotide glycohydrolase, and nicotinamide adenine dinucleotide pyrophosphatase activities.鼠伤寒沙门氏菌的吡啶核苷酸循环:烟酰胺腺嘌呤二核苷酸糖水解酶、烟酰胺单核苷酸糖水解酶和烟酰胺腺嘌呤二核苷酸焦磷酸酶活性的体外证明
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Pathways of nicotinamide adenine dinucleotide biosynthesis in nicotinic acid or nicotinamide requiring microorganisms.在需要烟酸或烟酰胺的微生物中烟酰胺腺嘌呤二核苷酸生物合成途径。
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Pyridine nucleotide cycle of Salmonella typhimurium: regulation of nicotinic acid phosphoribosyltransferase and nicotinamide deamidase.鼠伤寒沙门氏菌的吡啶核苷酸循环:烟酸磷酸核糖基转移酶和烟酰胺脱氨酶的调节
J Bacteriol. 1979 Jun;138(3):957-61. doi: 10.1128/jb.138.3.957-961.1979.
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Loss of protective antigen, histamine-sensitising factor and envelope polypeptides in cultural variants of Bordetella pertussis.
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