血红蛋白的自由基产生及氧化反应
Free-radical production and oxidative reactions of hemoglobin.
作者信息
Winterbourn C C
出版信息
Environ Health Perspect. 1985 Dec;64:321-30. doi: 10.1289/ehp.8564321.
Abstract
Mechanisms of autoxidation of hemoglobin, and its reactions with H2O2, O2-, and oxidizing or reducing xenobiotics are discussed. Reactive intermediates of such reactions can include drug free radicals, H2O2, and O2-, as well as peroxidatively active ferrylhemoglobin and methemoglobin-H2O2. The contributions of these species to hemoglobin denaturation and drug-induced hemolysis, and the actions of various protective agents, are considered.
摘要
讨论了血红蛋白的自氧化机制及其与过氧化氢、超氧阴离子以及氧化或还原异生物质的反应。此类反应的活性中间体可包括药物自由基、过氧化氢和超氧阴离子，以及具有过氧化活性的高铁血红蛋白和高铁血红蛋白 - 过氧化氢。考虑了这些物质对血红蛋白变性和药物诱导溶血的作用，以及各种保护剂的作用。
相似文献
1
Free-radical production and oxidative reactions of hemoglobin.血红蛋白的自由基产生及氧化反应
Environ Health Perspect. 1985 Dec;64:321-30. doi: 10.1289/ehp.8564321.
2
Haemoglobin oxidation and free radical production in the red cell.红细胞中的血红蛋白氧化与自由基生成
Biomed Biochim Acta. 1983;42(11-12):S134-8.
3
Role of oxygen and carbon radicals in hemoglobin oxidation.氧和碳自由基在血红蛋白氧化中的作用。
Arch Biochem Biophys. 1993 Apr;302(1):233-44. doi: 10.1006/abbi.1993.1205.
4
A novel antioxidant role for hemoglobin. The comproportionation of ferrylhemoglobin with oxyhemoglobin.血红蛋白的一种新的抗氧化作用。高铁血红蛋白与氧合血红蛋白的氧化还原平衡。
J Biol Chem. 1990 Nov 15;265(32):19453-60.
5
Generation of superoxide and hydrogen peroxide during interaction of nitrite with human hemoglobin.亚硝酸盐与人类血红蛋白相互作用过程中超氧化物和过氧化氢的生成。
Acta Med Okayama. 1981 Jun;35(3):173-8. doi: 10.18926/AMO/31285.
6
The reaction of hemoglobin with paraquat radicals in the presence and absence of O2.血红蛋白在有氧气和无氧气存在的情况下与百草枯自由基的反应。
Biochem Int. 1983 Jul;7(1):1-8.
7
Redox conversions of methemoglobin during redox cycling of quinones and aromatic nitrocompounds.醌类和芳香族硝基化合物氧化还原循环过程中高铁血红蛋白的氧化还原转化
Arch Biochem Biophys. 1994 Nov 15;315(1):170-6. doi: 10.1006/abbi.1994.1486.
8
Cross-linked hemoglobin-superoxide dismutase-catalase scavenges oxygen-derived free radicals and prevents methemoglobin formation and iron release.交联血红蛋白-超氧化物歧化酶-过氧化氢酶可清除氧衍生的自由基，并防止高铁血红蛋白的形成和铁的释放。
Biomater Artif Cells Immobilization Biotechnol. 1993;21(5):609-21. doi: 10.3109/10731199309117385.
9
Reactive oxygen species do not cause arsine-induced hemoglobin damage.活性氧不会导致胂诱导的血红蛋白损伤。
J Toxicol Environ Health. 1997 Apr 11;50(5):463-74. doi: 10.1080/00984109708984002.
10
Autoxidation reactions of hemoglobin A free from other red cell components: a minimal mechanism.
Biochem Biophys Res Commun. 1985 Oct 30;132(2):742-8. doi: 10.1016/0006-291x(85)91195-7.
引用本文的文献
1
The Molecular Pathology of Pre-Eclamptic Hypertension.子痫前期高血压的分子病理学
Curr Issues Mol Biol. 2025 May 20;47(5):375. doi: 10.3390/cimb47050375.
2
Biomolecular condensates-Prerequisites for anhydrobiosis?生物分子凝聚物——隐生现象的先决条件？
Protein Sci. 2025 Jul;34(7):e70192. doi: 10.1002/pro.70192.
3
Red blood cell metabolism: a window on systems health towards clinical metabolomics.红细胞代谢：通往临床代谢组学的系统健康之窗。
Curr Opin Hematol. 2025 May 1;32(3):111-119. doi: 10.1097/MOH.0000000000000863. Epub 2025 Mar 13.
4
Ferroptosis regulates hemolysis in stored murine and human red blood cells.铁死亡调节储存的小鼠和人类红细胞中的溶血。
Blood. 2025 Feb 13;145(7):765-783. doi: 10.1182/blood.2024026109.
5
Evaluation of erythrocyte membrane oxidation due to their exposure to shear flow generated by extracorporeal blood pump.评估红细胞膜因暴露于体外血泵产生的剪切流而发生的氧化。
Int J Artif Organs. 2024 Mar;47(3):155-161. doi: 10.1177/03913988241230942. Epub 2024 Feb 29.
6
Factors Influencing Venous Remodeling in the Development of Varicose Veins of the Lower Limbs.影响下肢静脉曲张静脉重塑的因素。
Int J Mol Sci. 2024 Jan 26;25(3):1560. doi: 10.3390/ijms25031560.
7
Oil from Mullet Roe Byproducts: Effect of Oil Extraction Method on Human Erythrocytes and Platelets.鲻鱼籽副产品油：油脂提取方法对人体红细胞和血小板的影响。
Foods. 2023 Dec 25;13(1):79. doi: 10.3390/foods13010079.
8
The artificial oxygen carrier erythrocruorin-characteristics and potential significance in medicine.人工氧载体血影蛋白的特性及其在医学中的潜在意义。
J Mol Med (Berl). 2023 Aug;101(8):961-972. doi: 10.1007/s00109-023-02350-3. Epub 2023 Jul 18.
9
Interactions of reactive sulfur species with metalloproteins.活性硫物种与金属蛋白的相互作用。
Redox Biol. 2023 Apr;60:102617. doi: 10.1016/j.redox.2023.102617. Epub 2023 Jan 27.
10
Hormesis and Oxidative Distress: Pathophysiology of Reactive Oxygen Species and the Open Question of Antioxidant Modulation and Supplementation.兴奋效应与氧化应激：活性氧的病理生理学以及抗氧化剂调节与补充的悬而未决问题。
Antioxidants (Basel). 2022 Aug 19;11(8):1613. doi: 10.3390/antiox11081613.
本文引用的文献
1
Coupled oxidation of ascorbic acid and haemoglobin: Quantitative studies on choleglobin formation. Estimation of haemoglobin and ascorbic acid oxidations.抗坏血酸与血红蛋白的偶联氧化：胆绿蛋白形成的定量研究。血红蛋白与抗坏血酸氧化的测定。
Biochem J. 1941 Mar;35(3):339-52. doi: 10.1042/bj0350339.
2
Reaction of methaemoglobin with hydrogen peroxide.高铁血红蛋白与过氧化氢的反应。
Nature. 1950 Sep 23;166(4221):513-4. doi: 10.1038/166513a0.
3
Catalase, peroxidase and metmyoglobin as catalysts of coupled peroxidatic reactions.过氧化氢酶、过氧化物酶和高铁肌红蛋白作为偶联过氧化物反应的催化剂。
Biochem J. 1955 Jun;60(2):310-25. doi: 10.1042/bj0600310.
4
GENERATION OF HYDROGEN PEROXIDE IN ERYTHROCYTES BY HEMOLYTIC AGENTS.溶血剂在红细胞中产生过氧化氢
Biochemistry. 1964 Jul;3:895-900. doi: 10.1021/bi00895a006.
5
NATURE OF THE IRON-OXYGEN BOND IN OXYHAEMOGLOBIN.氧合血红蛋白中铁-氧键的性质
Nature. 1964 Apr 4;202:83-4. doi: 10.1038/202083b0.
6
The mechanism of metmyoglobin oxidation.高铁肌红蛋白氧化的机制。
J Biol Chem. 1963 Apr;238:1520-8.
7
Free radical produced in the reaction of memyoglobin with hydrogen peroxide.肌红蛋白与过氧化氢反应产生的自由基。
Nature. 1958 May 17;181(4620):1398-9. doi: 10.1038/1811398a0.
8
9
The reduction of methemoglobin by phenylhydrazine under anaerobic conditions.
J Biol Chem. 1956 Aug;221(2):1047-55.
10
Oxidation of phenylhydrazines in the presence of oxyhaemoglobin and the origin of Heinz bodies in erythrocytes.在氧合血红蛋白存在的情况下苯肼的氧化作用以及红细胞中亨氏小体的起源。
Nature. 1954 Feb 27;173(4400):389-91. doi: 10.1038/173389b0.
Zotero 插件