Corn T H, Honig A, Thompson C, Bridges P K, Bartlett J R, Checkley S A
Br J Psychiatry. 1984 Apr;144:417-20. doi: 10.1192/bjp.144.4.417.
The growth hormone and hypotensive responses to clonidine have been measured in six drug free severely depressed patients before, and at two weeks after, the surgical procedure of stereotactic sub-caudate tractotomy. The responses were unaltered two weeks after operation, by which time a small clinical improvement was evident. These findings are discussed in relation to central alpha adrenoceptor functions in depression, and the effect upon this of antidepressant treatment.
