小细胞肺癌的骨髓受累模式。

Patterns of bone marrow involvement with small cell lung cancer.

作者信息

Clamon G H, Edwards W R, Hamous J E, Scupham R K

出版信息

Cancer. 1984 Jul 1;54(1):100-2. doi: 10.1002/1097-0142(19840701)54:1<100::aid-cncr2820540121>3.0.co;2-a.

DOI:10.1002/1097-0142(19840701)54:1<100::aid-cncr2820540121>3.0.co;2-a

Abstract

The extent of tumor involvement, necrosis, reticulin, and megakaryocytosis were assessed in 25 patients with small cell lung cancer in their bone marrow at diagnosis. The pattern of marrow involvement was compared with clinical outcome and tolerance of therapy. Any marrow involvement, no matter how minor, is a poor prognostic factor. Neither more extensive involvement, nor greater marrow fibrosis significantly worsened the prognosis.

摘要

对25例小细胞肺癌患者诊断时骨髓中的肿瘤累及范围、坏死情况、网状纤维及巨核细胞增多情况进行了评估。将骨髓受累模式与临床结局及治疗耐受性进行了比较。任何程度的骨髓受累，无论多么轻微，都是不良预后因素。更广泛的受累及更严重的骨髓纤维化均未显著恶化预后。