[使用正电子发射断层扫描术对苯二氮䓬受体进行的体内研究]
[In vivo study of benzodiazepine receptors using positron emission tomography].
作者信息
Maziere M, Prenant C, Sastre J, Crouzel M, Comar D, Cepeda C, Hantraye P, Kaijima M, Guibert B, Naquet R
出版信息
Encephale. 1983;9(4 Suppl 2):151B-160B.
The results obtained by positron-emission tomography in an "in vivo" study on the baboon using a benzodiazepine (flunitrazepam) labeled with carbon-11 are presented. The specificity of "in vivo" binding of Flunitrazepam-11C was demonstrated by competition with Lorazepam in the brain, but it was not possible to verify the criterium of stereospecificity "in vivo". The preliminary results of a study carried out under the same conditions on RO 15 1788 11C show the interest of using this labeled antagonist as an "in vivo" ligand for the specific binding sites of benzodiazepines in positron-emission tomography.
本文展示了在一项针对狒狒的“体内”研究中，使用碳 - 11标记的苯二氮䓬类药物（氟硝西泮）通过正电子发射断层扫描获得的结果。氟硝西泮 - 11C在大脑中的“体内”结合特异性通过与劳拉西泮竞争得以证明，但无法在“体内”验证立体特异性标准。在相同条件下对RO 15 1788 11C进行的一项研究的初步结果表明，在正电子发射断层扫描中，将这种标记的拮抗剂用作苯二氮䓬类药物特异性结合位点的“体内”配体具有重要意义。
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