[11C-Ro15-1788和11C-氟硝西泮，用于通过正电子发射断层扫描研究苯二氮䓬结合位点的两个坐标]
[11C-Ro15-1788 and 11C-flunitrazepam, two coordinates for the study by positron emission tomography of benzodiazepine binding sites].
作者信息
Mazière M, Prenant C, Sastre J, Crouzel M, Comar D, Hantraye P, Kaïsima M, Guibert B, Naquet R
出版信息
C R Seances Acad Sci III. 1983;296(18):871-6.
PMID:6136317
Abstract
In vivo binding of a benzodiazepine (flunitrazepam-C11) and a benzodiazepine antagonist (Ro 15-1788-C11) were studied with positron emission tomography. Advantages and disadvantages of each drug for studying specific in vivo binding sites are presented. The results obtained indicate that Ro 15-1788-C11 is a better in vivo radiocoordinat than flunitrazepam-C11.
摘要
采用正电子发射断层扫描技术研究了一种苯二氮䓬类药物（氟硝西泮 - C11）和一种苯二氮䓬类拮抗剂（Ro 15 - 1788 - C11）的体内结合情况。阐述了每种药物在研究特定体内结合位点方面的优缺点。所得结果表明，Ro 15 - 1788 - C11在体内作为放射性配位体比氟硝西泮 - C11表现更佳。
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