Blejer J L, Galassi N V, Saavedra V M, Nejamkis M R
Intervirology. 1984;21(3):174-7. doi: 10.1159/000149516.
2-day-old Wistar rats intracerebrally infected with the XJC13 strain of virus exhibited a 5% survival rate which rose to 71% after immune serum treatment. Brain viral titers were relatively unaffected by this treatment. Histologic studies showed necrosis in the cerebellum and brain cortex with mononuclear cell infiltration in both treated and nontreated groups. Beginning on day 16 postinfection, however, intracerebral perivascular gliosis foci and mild meningeal congestion were minimal in the treated animals. These findings imply that passively transferred humoral immunity leads to prompt recovery in this experimental model.
用病毒XJC13株脑内感染的2日龄Wistar大鼠存活率为5%，经免疫血清治疗后存活率升至71%。这种治疗对脑病毒滴度影响相对较小。组织学研究显示，治疗组和未治疗组的小脑和脑皮质均出现坏死并伴有单核细胞浸润。然而，从感染后第16天开始，治疗组动物脑内血管周围胶质增生灶和轻度脑膜充血情况较轻。这些发现表明，在该实验模型中，被动转移的体液免疫可促使病情迅速恢复。
