分子克隆的Friend水貂细胞灶性诱导病毒DNA的env基因和长末端重复序列的特征分析
Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNA.
作者信息
Adachi A, Sakai K, Kitamura N, Nakanishi S, Niwa O, Matsuyama M, Ishimoto A
出版信息
J Virol. 1984 Jun;50(3):813-21. doi: 10.1128/JVI.50.3.813-821.1984.
Abstract
The highly oncogenic erythroleukemia-inducing Friend mink cell focus-inducing (MCF) virus was molecularly cloned in phage lambda gtWES.lambda B, and the DNA sequences of the env gene and the long terminal repeat were determined. The nucleotide sequences of Friend MCF virus and Friend spleen focus-forming virus were quite homologous, supporting the hypothesis that Friend spleen focus-forming virus might be generated via Friend MCF virus from an ecotropic Friend virus mainly by some deletions. Despite their different pathogenicity, the nucleotide sequences of the env gene of Friend MCF virus and Moloney MCF virus were quite homologous, suggesting that the putative parent sequence for the generation of both MCF viruses and the recombinational mechanism for their generation might be the same. We compare the amino acid sequences in lymphoid leukemia-inducing ecotropic Moloney virus and Moloney MCF virus, and erythroblastic leukemia-inducing ecotropic Friend virus, Friend-MCF virus, and Friend spleen focus-forming virus. The Friend MCF virus long terminal repeat was found to be 550 base pairs long. This contained two copies of the 39-base-pair tandem repeat, whereas the spleen focus-forming virus genome contained a single copy of the same sequence.
摘要
具有高度致癌性的诱导红白血病的弗瑞德水貂细胞病灶诱导（MCF）病毒在噬菌体λgtWES.λB中进行了分子克隆，并测定了env基因和长末端重复序列的DNA序列。弗瑞德MCF病毒和弗瑞德脾病灶形成病毒的核苷酸序列相当同源，支持了这样一种假说，即弗瑞德脾病灶形成病毒可能主要通过一些缺失从亲嗜性弗瑞德病毒经由弗瑞德MCF病毒产生。尽管它们的致病性不同，但弗瑞德MCF病毒和莫洛尼MCF病毒的env基因核苷酸序列相当同源，这表明产生这两种MCF病毒的推定亲本序列及其产生的重组机制可能是相同的。我们比较了诱导淋巴细胞白血病的亲嗜性莫洛尼病毒和莫洛尼MCF病毒，以及诱导成红细胞白血病的亲嗜性弗瑞德病毒、弗瑞德-MCF病毒和弗瑞德脾病灶形成病毒中的氨基酸序列。发现弗瑞德MCF病毒的长末端重复序列长550个碱基对。它包含两个39个碱基对串联重复序列的拷贝，而脾病灶形成病毒基因组包含相同序列的单个拷贝。
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本文引用的文献
1
ASSAY FOR FRIEND LEUKEMIA VIRUS: RAPID QUANTITATIVE METHOD BASED ON ENUMERATION OF MACROSCOPIC SPLEEN FOCI IN MICE.Friend白血病病毒检测：基于小鼠脾脏肉眼可见病灶计数的快速定量方法。
Virology. 1964 Nov;24:513-8. doi: 10.1016/0042-6822(64)90199-0.
2
Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia.具有白血病特征的疾病在成年瑞士小鼠中的无细胞传播。
J Exp Med. 1957 Apr 1;105(4):307-18. doi: 10.1084/jem.105.4.307.
3
Speculations on RNA splicing.关于RNA剪接的推测。
Cell. 1981 Mar;23(3):643-6. doi: 10.1016/0092-8674(81)90425-6.
4
Analysis of the env gene of a molecularly cloned and biologically active Moloney mink cell focus-forming proviral DNA.对分子克隆且具有生物活性的莫洛尼貂细胞病灶形成前病毒DNA的env基因进行分析。
J Virol. 1982 Oct;44(1):19-31. doi: 10.1128/JVI.44.1.19-31.1982.
5
Primary structure of glycoprotein glycans: basis for the molecular biology of glycoproteins.糖蛋白聚糖的一级结构：糖蛋白分子生物学的基础
Adv Carbohydr Chem Biochem. 1980;37:157-223. doi: 10.1016/s0065-2318(08)60021-9.
6
Envelope gene sequences which encode the gp52 protein of spleen focus-forming virus are required for the induction of erythroid cell proliferation.编码脾集落形成病毒gp52蛋白的包膜基因序列是诱导红细胞增殖所必需的。
J Virol. 1982 Jul;43(1):223-33. doi: 10.1128/JVI.43.1.223-233.1982.
7
Analysis of the expression of spleen focus-forming virus (SFFV)-related RNA and gp55, a Friend and Rauscher virus-specific protein.脾集落形成病毒（SFFV）相关RNA及gp55（一种Friend病毒和Rauscher病毒特异性蛋白）表达的分析。
Virology. 1980 Dec;107(2):331-44. doi: 10.1016/0042-6822(80)90301-3.
8
RNAs of defective and nondefective components of Friend anemia and polycythemia virus strains identified and compared.对弗瑞德贫血和红细胞增多症病毒株的缺陷和非缺陷成分的RNA进行了鉴定和比较。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 2,:823-35. doi: 10.1101/sqb.1980.044.01.087.
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10
Analysis of spleen focus-forming virus-specific RNA sequences coding for spleen focus-forming virus-specific glycoprotein with a molecular weight of 55,000 (gp55).对编码分子量为55,000的脾集落形成病毒特异性糖蛋白（gp55）的脾集落形成病毒特异性RNA序列的分析。
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