促肾上腺皮质激素释放因子41可刺激正常人体释放β-促脂解素和β-内啡肽。
CRF-41 stimulates the release of beta-lipotrophin and beta-endorphin in normal human subjects.
作者信息
McLoughlin L, Tomlin S, Grossman A, Lytras N, Schally A V, Coy D, Besser G M, Rees L H
出版信息
Neuroendocrinology. 1984 Apr;38(4):282-4. doi: 10.1159/000123904.
PMID:6328343
Abstract
A prompt rise in circulating immunoreactive N- and C-terminal lipotrophin (LPH) accompanied the increase in ACTH when 100 micrograms CRF-41 was given to 6 normal male subjects. Chromatography of the basal and peak 15-min values showed that there was an equimolar increase in beta-LPH and beta-endorphin, to cause parallel release of ACTH, beta-endorphin and beta-LPH from the pro-opiocortin precursor.
摘要
当给6名正常男性受试者注射100微克促肾上腺皮质激素释放因子-41（CRF-41）时，循环中免疫反应性N端和C端促脂素（LPH）迅速升高，同时促肾上腺皮质激素（ACTH）也增加。对基础值和15分钟峰值进行色谱分析表明，β-LPH和β-内啡肽呈等摩尔增加，从而导致促肾上腺皮质激素原前体平行释放出促肾上腺皮质激素、β-内啡肽和β-LPH。
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