大鼠脑中的14-3-2蛋白。

14-3-2 protein in rat brain.

作者信息

Persson L, Rönnbäck L, Grasso A, Haglid K G, Hansson H A, Dolonius L, Molin S O, Nygren H

出版信息

J Neurol Sci. 1978 Feb;35(2-3):381-90. doi: 10.1016/0022-510x(78)90018-7.

Abstract

The distribution of the 14-3-2 protein in rat brain was investigated by immuno-electron microscopy using antiserum to the protein conjugated with peroxidase. 14-3-2 was demonstrated in the nuclear membrane, the endoplasmic reticular membranes and in the plasma membrane of nerve cells. The protein was also localized to the presynaptic densities and to the pre- and postsynaptic membranes. It could not be demonstrated in the membranes of the Golgi complex, inner membrane of mitochondria or in the nucleoplasm of neurons. No 14-3-2 protein was found in astrocytes, oligodendrocytes or in non-neuroectodermal tissue elements.

摘要

使用与过氧化物酶偶联的该蛋白抗血清，通过免疫电子显微镜研究了14 - 3 - 2蛋白在大鼠脑中的分布。在神经细胞核膜、内质网膜和质膜中证实有14 - 3 - 2蛋白。该蛋白也定位于突触前致密区以及突触前和突触后膜。在高尔基体复合体膜、线粒体内膜或神经元核质中未证实有该蛋白。在星形胶质细胞、少突胶质细胞或非神经外胚层组织成分中未发现14 - 3 - 2蛋白。