肾小球基底膜的Goodpasture抗原：定位于IV型胶原的非胶原区域。
Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.
作者信息
Wieslander J, Barr J F, Butkowski R J, Edwards S J, Bygren P, Heinegård D, Hudson B G
出版信息
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3838-42. doi: 10.1073/pnas.81.12.3838.
The glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen isolated from glomerular basement membrane contains collagenase-resistant sequences within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent assay, and chemical analysis were used to demonstrate that the collagenase-resistant sequences of type IV collagen contain Goodpasture antigen.
肺出血肾炎综合征中的肾小球基底膜抗原是一种抗胶原酶分子，单体分子量约为26,000。从肾小球基底膜分离出的IV型胶原在其结构中含有抗胶原酶序列。采用聚丙烯酰胺凝胶电泳、酶联免疫吸附测定和化学分析来证明IV型胶原的抗胶原酶序列含有肺出血肾炎综合征抗原。
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