通过静脉注射抗IV型胶原抗体和抗层粘连蛋白抗体诱导小鼠产生的类Goodpasture综合征。

Yaar M, Foidart J M, Brown K S, Rennard S I, Martin G R, Liotta L

Am J Pathol. 1982 Apr;107(1):79-91.

Laminin and Type IV collagen are both components of basement membrane. Antibodies to these two proteins, when injected into mice, were found to accumulate in all basement membranes examined, but at highest levels in kidney, liver, and spleen. An acute respiratory distress syndrome was noted shortly after injection. A transient segmental proliferative glomerulonephritis was observed both in the heterologous (early) and autologous (late) phase. The glomerular basement membrane of mice injected with anti-Type IV collagen antibodies was observed to be thickened and to contain dense deposits in the lamina rara externa and lamina rara interna.

层粘连蛋白和IV型胶原蛋白都是基底膜的组成成分。将针对这两种蛋白质的抗体注射到小鼠体内后，发现它们在所有检测的基底膜中都有积累，但在肾脏、肝脏和脾脏中的积累水平最高。注射后不久便出现了急性呼吸窘迫综合征。在异源（早期）和同源（晚期）阶段均观察到短暂的节段性增殖性肾小球肾炎。观察到注射抗IV型胶原蛋白抗体的小鼠的肾小球基底膜增厚，在外侧稀疏层和内侧稀疏层中含有致密沉积物。