Stjernquist M, Owman C
Regul Pept. 1984 Mar;8(2):161-7. doi: 10.1016/0167-0115(84)90171-x.
VIP inhibits the spontaneous motor activity (including tone) in isolated preparations of uterine cervix from oophorectomized rats, but has no direct effect on preparations from estrogen-treated animals. Electrical field stimulation of nerves in the tissue evokes a contractile response that is inhibited by VIP in a concentration-dependent manner. The neuronal link probably involves a cholinergic mechanism, since the contraction is blocked by atropine. The results suggest the presence of VIP receptors both in cholinergic nerves and in smooth muscle cells of the rat uterine cervix.
血管活性肠肽（VIP）可抑制去卵巢大鼠离体子宫颈制剂的自发运动活性（包括张力），但对雌激素处理动物的制剂无直接作用。对组织中的神经进行电场刺激会引发收缩反应，VIP可浓度依赖性地抑制该反应。这种神经元联系可能涉及胆碱能机制，因为阿托品可阻断该收缩反应。结果表明，大鼠子宫颈的胆碱能神经和平滑肌细胞中均存在VIP受体。
