Lee Jong-Kang, Tyan Yeu-Sheng, Huang Wen-Sheng
Department of Nuclear Medicine, Chung Shan University Hospital, Taichung, Taiwan.
Eur J Nucl Med Mol Imaging. 2004 Apr;31(4):528-31. doi: 10.1007/s00259-003-1428-2. Epub 2004 Jan 14.
This study was designed to compare the effectiveness of thallium-201 single-photon emission tomography (SPET) and conventional imaging, comprising computed tomography (CT) and magnetic resonance imaging (MRI), in the detection of residual/recurrent squamous cell carcinoma (SCC) of the oral cavity. Thirty-two patients with clinically suspected recurrent SCC of the oral cavity were recruited. All patients underwent (201)Tl SPET and CT or MRI within 2 weeks. The final diagnoses were based on the histology of the biopsy specimen. (201)Tl SPET and CT/MRI both accurately detected 17 of 18 residual/recurrent tumours. CT/MRI yielded eight false-positive studies, whereas (201)Tl SPET successfully excluded all tumours. The sensitivity, specificity, positive and negative predictive values and accuracy of (201)Tl SPET for the detection of recurrent oral SCC were 94%, 100%, 100%, 93% and 97%, respectively. The sensitivity, specificity, positive and negative predictive values and accuracy of CT/MRI for the detection of recurrent oral SCC were 94%, 43%, 68%, 86% and 72%, respectively. Thallium-201 SPET is more accurate than conventional imaging (CT or MRI) in differentiating residual/recurrent oral SCC from post-therapy changes.
本研究旨在比较铊 - 201单光子发射断层扫描（SPET）与包括计算机断层扫描（CT）和磁共振成像（MRI）在内的传统成像技术在检测口腔鳞状细胞癌（SCC）残留/复发方面的有效性。招募了32例临床怀疑口腔SCC复发的患者。所有患者在2周内接受了铊 - 201 SPET及CT或MRI检查。最终诊断基于活检标本的组织学检查。铊 - 201 SPET和CT/MRI均准确检测出18例残留/复发肿瘤中的17例。CT/MRI产生了8例假阳性结果，而铊 - 201 SPET成功排除了所有肿瘤。铊 - 201 SPET检测复发性口腔SCC的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为94%、100%、100%、93%和97%。CT/MRI检测复发性口腔SCC的敏感性、特异性、阳性预测值、阴性预测值和准确性分别为94%、43%、68%、86%和72%。在区分残留/复发性口腔SCC与治疗后改变方面，铊 - 201 SPET比传统成像（CT或MRI）更准确。
