Khansari N, Whitten H D, Fudenberg H H
Science. 1984 Jul 6;225(4657):76-8. doi: 10.1126/science.6328664.
Phencyclidine ("PCP" or "angel dust") and some of its derivatives are psychotomimetic drugs that have been used in general anesthesia for some time. This drug blocks potassium ion channels in brain tissue, and there is a specific PCP binding to lymphocytes. In a study of the effects of this drug on immunocyte function, it was found that humoral and cellular immune responses in vitro were depressed when immunocytes were treated with PCP before biological assay. This finding has implications for PCP abuse and also for the use of its derivative in general anesthesia, where it may contribute to postoperative infection.
苯环己哌啶（“PCP”或“天使尘”）及其一些衍生物是致幻药物，已在全身麻醉中使用了一段时间。这种药物会阻断脑组织中的钾离子通道，并且有一种特定的PCP与淋巴细胞结合。在一项关于这种药物对免疫细胞功能影响的研究中发现，在生物测定前用PCP处理免疫细胞时，体外的体液免疫和细胞免疫反应会受到抑制。这一发现对PCP滥用以及其衍生物在全身麻醉中的使用都有影响，在全身麻醉中它可能会导致术后感染。
