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[成人肾母细胞瘤]

[Wilms' tumor in adults].

作者信息

Matveev B P, Bukharkin B V, Gotsadze D T

出版信息

Vopr Onkol. 1984;30(5):68-72.

PMID:6328762
Abstract

Wilms' tumor occurs extremely rarely in adults. There is no consensus in the literature on the problems of clinical manifestations, diagnosis and treatment of the disease. Ten adult patients (aged 16-29) with Wilms' tumor formed the study group. They made up 0.9 per cent of the total number of kidney tumor patients. The peculiarities of the clinical course that distinguish adult nephroblastoma from renal cancer and Wilms' tumor of the infancy were analysed. The latent period appeared to be long. Problems of diagnosis are discussed. Angiography proved to be of the highest diagnostic value. Complex treatment including transperitoneal nephrectomy, radiation and chemotherapy was carried out in 7 cases, palliative chemotherapy and radiation treatment--in 3. Unlike pediatric nephroblastoma, Wilms' tumor in adults was resistant to radiation. Treatment results still remained unsatisfactory: 6 patients died 7-19 months after the beginning of treatment.

摘要

成人肾母细胞瘤极为罕见。关于该疾病的临床表现、诊断及治疗问题,文献中尚无共识。十名成年肾母细胞瘤患者(年龄在16至29岁之间)组成了研究组。他们占肾肿瘤患者总数的0.9%。分析了成人肾母细胞瘤与肾癌及婴幼儿肾母细胞瘤在临床病程上的差异。潜伏期似乎较长。讨论了诊断问题。血管造影术显示具有最高的诊断价值。7例患者接受了包括经腹肾切除术、放疗及化疗在内的综合治疗,3例接受了姑息性化疗及放疗。与儿童肾母细胞瘤不同,成人肾母细胞瘤对放疗耐药。治疗结果仍不尽人意:6例患者在治疗开始后7至19个月死亡。

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