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成人肾母细胞瘤:一例病例报告及文献复习

Wilms' tumor in an adult: a case report and review of the literature.

作者信息

Butler D, Buchino J J, Jose B, Lindberg R D, Spanos W J, Paris K J

机构信息

Department of Radiation Oncology, James Graham Brown Cancer Center, School of Medicine, University of Louisville, Kentucky 40292, USA.

出版信息

J Ky Med Assoc. 1997 May;95(5):191-6.

PMID:9149498
Abstract

Wilms' tumor in an adult is extremely rare, with less than 250 cases reported in the world literature. Treatment guidelines for pediatric Wilms' tumor are well established; those for adults are not. This article presents the case of a 19-year-old male diagnosed with Wilms' tumor after complaints of hematuria. He was categorized as Stage IV after nephrectomy and received post-operative radiotherapy and chemotherapy consisting of Vincristine, Adriamycin, and Actinomycin-D. Two years later he was found to have metastases to brain and lungs. He was treated with radiotherapy and bone marrow transplantation, and died of septic shock. The literature regarding Wilms' tumor in adults is reviewed, and current therapy is discussed.

摘要

成人肾母细胞瘤极为罕见,世界文献报道的病例不足250例。儿童肾母细胞瘤的治疗指南已很完善;而成人肾母细胞瘤的治疗指南则尚未确立。本文介绍了一名19岁男性的病例,该患者因血尿就诊后被诊断为肾母细胞瘤。肾切除术后,他被归类为IV期,并接受了术后放疗和由长春新碱、阿霉素和放线菌素-D组成的化疗。两年后,发现他出现了脑和肺转移。他接受了放疗和骨髓移植治疗,最终死于感染性休克。本文回顾了有关成人肾母细胞瘤的文献,并讨论了当前的治疗方法。

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