Wojtecka-Lukasik E, Maśliński S
Agents Actions. 1984 Apr;14(3-4):451-3. doi: 10.1007/BF01973847.
Experimental pleurisy in rat and intraperitoneal injection of histamine, serotonin and the histamine releaser compound 48/80 caused changes in blood leucocyte populations. An increased number of PMN-leucocytes was observed. The peripheral blood PMN-leucocytes of non-treated rats contained collagenase mainly in the latent form. During experimental pleurisy and after treatment with histamine, serotonin and compound 48/80 activation of latent collagenase of up to 90-98% was obtained. Mepyramine, cimetidine and timegadine inhibited activation of latent collagenase by compound 48/80. It is suggested that histamine is involved in the process of activation of leucocyte collagenase in the course of inflammation.
大鼠实验性胸膜炎以及腹腔注射组胺、5-羟色胺和组胺释放化合物48/80会导致血液白细胞群体发生变化。观察到多形核白细胞数量增加。未处理大鼠的外周血多形核白细胞中的胶原酶主要以潜伏形式存在。在实验性胸膜炎期间以及用组胺、5-羟色胺和化合物48/80处理后，潜伏胶原酶的激活率高达90%-98%。美吡拉敏、西咪替丁和替美加定可抑制化合物48/80对潜伏胶原酶的激活。提示组胺参与炎症过程中白细胞胶原酶的激活过程。
