Horoupian D S, Pick P, Spigland I, Smith P, Portenoy R, Katzman R, Cho S
Ann Neurol. 1984 May;15(5):502-5. doi: 10.1002/ana.410150518.
A 35-year-old homosexual man with acquired immune deficiency syndrome developed progressive dementia and spastic quadriparesis over a two-month period. Severe symmetrical, bilateral degeneration of the corticospinal and frontopontine fibers and cerebellar white matter were found postmortem. Several glial nodules in the brainstem and cerebellum suggested "smoldering" brainstem encephalitis. The possible association of the adenovirus that was isolated from the patient's cerebrospinal fluid to these obscure changes in the central nervous system is discussed.
一名35岁的获得性免疫缺陷综合征同性恋男子在两个月内出现进行性痴呆和痉挛性四肢瘫。尸检发现皮质脊髓束和额桥纤维以及小脑白质严重对称性双侧变性。脑干和小脑中的几个胶质结节提示存在“隐匿性”脑干脑炎。讨论了从患者脑脊液中分离出的腺病毒与中枢神经系统这些不明变化之间可能存在的关联。
