人类免疫缺陷病毒1型中枢神经系统感染模型。
models of HIV-1 infection of the Central Nervous System.
作者信息
Faia Celeste, Plaisance-Bonstaff Karlie, Peruzzi Francesca
机构信息
Louisiana State University Health Sciences Center and S Stanley Scott Cancer Center.
Department of Microbiology Immunology and Parasitology.
出版信息
Drug Discov Today Dis Models. 2020 Fall;32(Pt A):5-11. doi: 10.1016/j.ddmod.2019.10.007. Epub 2019 Dec 20.
Abstract
Neurocognitive disorders associated with HIV-1 infection affect more than half of persons living with HIV (PLWH) under retroviral therapy. Understanding the molecular mechanisms and the complex cellular network communication underlying neurological dysfunction is critical for the development of an effective therapy. As with other neurological disorders, challenges to studying HIV infection of the brain include limited access to clinical samples and proper reproducibility of the complexity of brain networks in cellular and animal models. This review focuses on cellular models used to investigate various aspects of neurological dysfunction associated with HIV infection.
摘要
与HIV-1感染相关的神经认知障碍影响了超过一半接受抗逆转录病毒治疗的HIV感染者（PLWH）。了解神经功能障碍背后的分子机制和复杂的细胞网络通讯对于开发有效的治疗方法至关重要。与其他神经疾病一样，研究HIV感染大脑面临的挑战包括临床样本获取有限以及细胞和动物模型中大脑网络复杂性的适当可重复性。本综述重点关注用于研究与HIV感染相关的神经功能障碍各个方面的细胞模型。
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